SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
نویسندگان
چکیده
A genome-wide association study identified a common genetic variant rs4939827 at 18q21 in SMAD7 to be related with colorectal cancer (CRC) risk with OR=1.2 and P =7.80E-28. Until recently, several meta-analysis studies have been conducted, and reported significant association between rs4939827 and CRC risk. However none of these studies evaluated the potential association between rs4939827 and CRC risk in Chinese population. In this study, we evaluated this association by a meta-analysis using 12077 samples including 5816 CRC cases and 6261 controls. In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
منابع مشابه
SMAD7 Variant rs4939827 Is Associated with Colorectal Cancer Risk in Croatian Population
BACKGROUND Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed. AIM The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, r...
متن کاملA Common SMAD7 Variant Is Associated with Risk of Colorectal Cancer: Evidence from a Case-Control Study and a Meta-Analysis
BACKGROUND A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results. METHOD AND FINDINGS We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then perf...
متن کاملA case-control study: association of SMAD7 single nucleotide polymorphisms with colorectal cancer in the Han population
Recent genome-wide studies and analyses of the TGF-β pathway have identified a risk locus among the Caucasian population for colorectal cancer (CRC). This risk locus is located at 18q21, which maps to the SMAD7 gene. As a result, the CRC susceptibility loci identified thus far among Caucasians cannot be used to predict the risk of CRC in Chinese Han population. A Chinese Han population case-con...
متن کاملMultiple Functional Risk Variants in a SMAD7 Enhancer Implicate a Colorectal Cancer Risk Haplotype
Genome-wide association studies (GWAS) of colorectal cancer (CRC) have led to the identification of a number of common variants associated with modest risk. Several risk variants map within the vicinity of TGFβ/BMP signaling pathway genes, including rs4939827 within an intron of SMAD7 at 18q21.1. A previous study implicated a novel SNP (novel 1 or rs58920878) as a functional variant within an e...
متن کاملSMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies
Mothers against decapentaplegic homolog 7 (SMAD7) inhibits the transforming growth factor-β (TGF-β) signaling pathway, which regulates carcinogenesis and cancer progression. A number of studies have reported that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) are associated with colorectal cancer (CRC) risk, but the results from these studies remain conflicting. To determine a more ...
متن کامل